Open AccessUterine malignant mixed müllerian tumor camouflaging as pelvic sarcoma
Author(s) -
Vidya Monappa,
Ranjini Kudva,
Roumina Hasan
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.157325
Subject(s) - histogenesis , immunohistochemistry , uterus , pathology , sarcoma , medicine , müllerian mimicry , adenocarcinoma , mixed tumor , endometrium , carcinosarcoma , endometriosis , carcinoma , cancer
Malignant mixed Müllerian tumors (MMMTs) of the uterus are rare, aggressive tumors that present at an advanced stage and are associated with poor prognosis. They arise as a result of divergent carcinomatous and mesenchymal differentiation of tumor stem cells. Rarely one of the components may predominate contributing to diagnostic confusion. We present a rare case of uterine MMMT arising in endometrial adenocarcinoma, camouflaging as pelvic sarcoma with a major sarcomatous component. This case report highlights the importance of thorough tissue sampling and the role of immunohistochemistry (IHC) in arriving at an accurate diagnosis. This case also demonstrates the conversion theory of histogenesis of MMMTs.