Open AccessBreast carcinoma with numerous large "thanatosomes"
Author(s) -
N K Panicker,
Archana Buch,
Anand Patel
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.157304
Subject(s) - hyaline , pathology , eosinophilic , carcinoma , breast carcinoma , pathogenesis , stromal cell , medicine , biology , breast cancer , cancer
Intracytoplasmic and stromal eosinophilic hyaline globules (HGs) have been observed in various neoplastic and nonneoplastic conditions. Thanatosomes are also such HGs seen invariably associated with increased apoptosis and may contain nuclear fragments, occasionally observed in high-grade tumors. We are reporting a case of high-grade breast carcinoma with this striking morphological feature. Their probable nature, pathogenesis, and significance are discussed with review of literature.