Effects of cisplatin on potassium currents in CT26 cells | Zendy

Seong Kyu Han | Zendy; Naveen Sharma | Zendy; Janardhan P. Bhattarai | Zendy; Sun Young Kim | Zendy; PyoungHan Hwang | Zendy; Min Sun Kim | Zendy

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Effects of cisplatin on potassium currents in CT26 cells

Author(s) -

Seong Kyu Han,

Naveen Sharma,

Janardhan P. Bhattarai,

Sun Young Kim,

PyoungHan Hwang,

Min Sun Kim

Publication year - 2016

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.154085

Subject(s) - potassium , cisplatin , potassium channel , chemistry , iberiotoxin , patch clamp , tetraethylammonium , potassium channel blocker , membrane potential , apoptosis , biophysics , pharmacology , biochemistry , medicine , biology , receptor , organic chemistry , chemotherapy

Cisplatin, a platinum-based drug, is an important weapon against many types of cancer. It is well-known that cisplatin induces apoptosis. Potassium channel plays very important role in several signaling pathways. To investigate the possibility that potassium channels also have a role in the cellular response to cisplatin, we examined the effect of cisplatin on the activity of potassium channels on CT26 cell, the colon carcinoma cell line.

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