Open AccessEffects of cisplatin on potassium currents in CT26 cells
Author(s) -
Naveen Sharma,
Janardhan P. Bhattarai,
Sun Young Kim,
Pyoung Han Hwang,
Min Sun Kim,
Seong Kyu Han
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.154085
Subject(s) - potassium , cisplatin , potassium channel , chemistry , iberiotoxin , patch clamp , tetraethylammonium , potassium channel blocker , membrane potential , apoptosis , biophysics , pharmacology , biochemistry , medicine , biology , receptor , organic chemistry , chemotherapy
Cisplatin, a platinum-based drug, is an important weapon against many types of cancer. It is well-known that cisplatin induces apoptosis. Potassium channel plays very important role in several signaling pathways. To investigate the possibility that potassium channels also have a role in the cellular response to cisplatin, we examined the effect of cisplatin on the activity of potassium channels on CT26 cell, the colon carcinoma cell line.