Open AccessInsights into significant pathways and gene interaction networks in peripheral blood mononuclear cells for early diagnosis of hepatocellular carcinoma
Author(s) -
Jian Jiang,
Chao Yu,
Zhi Peng Li,
Jie Xiao,
Hao Zhang,
Mei Yuan Chen,
Cheng Yi Sun
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.154081
Subject(s) - kegg , peripheral blood mononuclear cell , hepatocellular carcinoma , gene , gene expression , biology , microarray , microarray analysis techniques , biological pathway , gene expression profiling , cancer research , immunology , transcriptome , genetics , in vitro
Early diagnosis of hepatocellular cancer (HCC) significantly helps improve patient survival. However, high specific and sensitive tests for screening patients with early stage of HCC are not yet available. Novel HCC biomarkers based on gene expression profiles of peripheral blood mononuclear cells (PBMCs) might change the situation. Recently, a three gene-based signature for the non-invasive detection of early HCC was reported.