Oxaliplatin-induced acute thrombocytopenia | Zendy

GokmenUmut Erdem | Zendy; Mutlu Doğan | Zendy; Nebi Serkan Demirci | Zendy; Nurullah Zengin | Zendy

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Oxaliplatin-induced acute thrombocytopenia

Author(s) -

GokmenUmut Erdem,

Mutlu Doğan,

Nebi Serkan Demirci,

Nurullah Zengin

Publication year - 2016

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.154056

Subject(s) - oxaliplatin , medicine , neurotoxicity , toxicity , gastroenterology , pharmacology , immunology , cancer , colorectal cancer

Oxaliplatin (1, 2-diamminocyclohexaneoxalato-platinum) is a novel platin analog, which is widely used in gastrointestinal malignancies. Platinum analogs damage cellular deoxyribonucleic acid (DNA) by leading covalent bifunctional DNA adducts with cellular DNA. Major side effects of oxaliplatin are neurotoxicity (peripheral neuropathy), myelosuppression with moderate thrombocytopenia and gastrointestinal toxicity (diarrhea). Thrombocytopenia might be related to myelosuppression and/or drug-induced immune thrombocytopenia (DIIT). In here, oxaliplatin-induced thrombocytopenia is discussed with review of the literature.

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