Open AccessEvaluation of the radioprotective effect of Turkish propolis on foreskin fibroblast cells
Author(s) -
Can Özgür Yalçın,
Yüksel Aliyazıcıoğlu,
Selim Demir,
İbrahim Turan,
Zümrüt Bahat,
Sema Mısır,
Orhan Değer
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.154050
Subject(s) - propolis , fibroblast , polyphenol , chemistry , amifostine , dna damage , comet assay , foreskin , genotoxicity , antioxidant , traditional medicine , dna , pharmacology , biochemistry , food science , in vitro , cell culture , biology , toxicity , medicine , genetics , organic chemistry
Propolis is a resinous bee product, rich of polyphenolic compounds and flavonoids. It is known that in different geographic zones its chemical composition varies due to the different plant sources. Many biological properties including antimicrobial, antioxidative, anti-inflammatory, antitumoral, antigenotoxic, antimutagenic, cytostatic activities have been ascribed to propolis. These biological effects are predominantly attributed to its content of polyphenols. In this study, we aimed to evaluate the radioprotective effect of ethanolic extract of Turkish propolis. (EETP) against γ-ray-induced DNA damage on fibroblast cells using comet assay for the first time.