Open AccessOxidative stress marker in oral cancer: A review
Author(s) -
Payal Katakwar,
Rashmi Metgud,
Smitha Naik,
Rashu Mittal
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.151935
Subject(s) - reactive oxygen species , oxidative stress , carcinogenesis , superoxide , dna damage , hydrogen peroxide , cancer , chemistry , hydroxyl radical , carcinogen , apoptosis , singlet oxygen , cancer cell , oxidative phosphorylation , microbiology and biotechnology , cancer research , biochemistry , biology , dna , oxygen , antioxidant , enzyme , genetics , organic chemistry
Oxygen derived species such as hydrogen peroxide, superoxide anion radical, hydroxyl radical (OH-), and singlet oxygen are well known to be cytotoxic and have been implicated in the etiology of a wide array of human diseases, including cancer. Various carcinogens may also partly exert their effect by generating reactive oxygen species (ROS) during their metabolism. Oxidative damage to cellular DNA can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. ROS influences central cellular processes such as proliferation, apoptosis, and senescence which are implicated in the development of cancer. Understanding the role of ROS as key mediators in signaling cascades may provide various opportunities for pharmacological intervention.