Open AccessDifferent effects of the three polymorphisms on 15q25.1 onlung cancer risk: Evidence from published literatures
Author(s) -
Huiling Sun,
Yuqin Pan,
Bangshun He,
Qiwen Deng,
Hou-Qun Ying,
Jie Chen,
Xian Lu,
Shukui Wang
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.151863
Subject(s) - lung cancer , meta analysis , oncology , medicine , single nucleotide polymorphism , genetic association , lung cancer susceptibility , biology , genotype , genetics , gene
Genetic studies have shown a significant association between lung cancer risk and single nucleotide polymorphisms on chromosome 15q25.1. The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent. The aim of meta-analysis was toclarify the link between three polymorphisms and susceptibility to lung cancer.