Open AccessCombined therapeutic effect and molecular mechanisms of metformin and cisplatin in human lung cancer xenografts in nude mice
Author(s) -
Yuqin Chen,
Gang Chen
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.151444
Subject(s) - survivin , cisplatin , metformin , vascular endothelial growth factor , lung cancer , medicine , cancer research , pharmacology , immunohistochemistry , cancer , messenger rna , nude mouse , vascular endothelial growth factor a , chemotherapy , endocrinology , biology , vegf receptors , diabetes mellitus , biochemistry , gene
This work was aimed at studying the inhibitory activity of metformin combined with the commonly used chemotherapy drug cisplatin in human lung cancer xenografts in nude mice. We also examined the combined effects of these drugs on the molecular expression of survivin, matrix metalloproteinase-2 (MMP-2), vascular endothelial growth factor-C (VEGF-C), and vascular endothelial growth factor receptor-3 (VEGFR-3) to determine the mechanism of action and to explore the potential applications of the new effective drug therapy in lung cancer.