Open AccessDendritic cell vaccination enhances antiangiogenesis induced by endostatin in rat glioma
Author(s) -
Xingyi Zhou,
Yixiang Liao,
Haoyu Li,
Zijin Zhao,
Qing Liu
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.151430
Subject(s) - glioma , angiogenesis , endostatin , vascular endothelial growth factor , immune system , western blot , immunology , immunohistochemistry , dendritic cell , vaccination , cancer research , cell adhesion molecule , biology , medicine , vegf receptors , biochemistry , gene
It has been verified that dendritic cell (DC) vaccination can improve the prognosis of malignant glioma. However, recent evidence suggests the problems with DC vaccines lies, at least in part, with the cancers ability to induce an immunosupressive response that suppresses any vaccine-mediated active immunity. Our previous studies indicate that subcutaneous vaccine can restrain the cancer cells implanted in the brain, but the effect is limited on vascularized tumor in the brain. Furthermore, vascular endothelial growth factor (VEGF) and vascular cell adhesion molecule (VCAM) play an important role in immunoevasion.