Open AccessEvaluation of transforming growth factor beta1 gene in oral submucous fibrosis induced in Sprague-Dawley rats by injections of areca nut and pan masala (commercial areca nut product) extracts
Author(s) -
Shilpa Maria,
Venkatesh V Kamath,
Krishnanand Satelur,
Komali Rajkumar
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.148729
Subject(s) - oral submucous fibrosis , areca , fibrosis , transforming growth factor , medicine , real time polymerase chain reaction , epithelium , pathology , biology , nut , gene , biochemistry , structural engineering , engineering
Oral submucous fibrosis (OSF) is a potentially malignant oral disorder causally linked to the habit of chewing arecanut. The pathogenesis of the disorder is multifactorial and transforming growth factor beta (TGF-beta) is a prominent player in the induction of fibrosis. The alkaloids of the arecanut seem to target the TGF-beta and the deposition of collagen is predominantly mediated through this cytokine.