DPYD*2A/*5A/*9A and UGT1A1*6/*28 polymorphisms in Chinese colorectal cancer patients | Zendy

Guoyin Li | Zendy; Jianfeng Duan | Zendy; Wanjun Li | Zendy; Tao Liu | Zendy

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DPYD*2A/*5A/*9A and UGT1A1*6/*28 polymorphisms in Chinese colorectal cancer patients

Author(s) -

Guoyin Li,

Jianfeng Duan,

Wanjun Li,

Tao Liu

Publication year - 2016

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.148685

Subject(s) - dpyd , irinotecan , genotype , fluorouracil , colorectal cancer , medicine , oncology , gastroenterology , chemotherapy , biology , pharmacogenetics , cancer , genetics , gene

Fluorouracil drugs and irinotecan are commonly used in the treatment of colorectal cancer (CRC), but some patients have severe toxic side effects in the conventional dose. DPYD*2A/*5A/*9A and UGT1A1 * 6/*28 polymorphisms are related to the toxicity of fluorouracil drugs and irinotecan, respectively. Herein, we investigated the frequencies of DPYD*2A/*5A/*9A and UGT1A1 * 6/*28 genotypes in Chinese CRC patients.

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