Open AccessAbberent expression of oncogenic and tumor-suppressive microRNAs and their target genes in human adenocarcinoma alveolar basal epithelial cells
Author(s) -
Elham Tafsiri,
Mojtaba Darbouy,
Mohammad Behgam Shadmehr,
William C. Cho,
Morteza Karimipoor
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.148673
Subject(s) - microrna , a549 cell , biology , gene , adenocarcinoma , cancer research , gene expression , microbiology and biotechnology , complementary dna , cell culture , cancer , genetics
Lung cancer is one of the most serious types of cancer that often diagnosed at advanced stage. MicroRNAs (miRNAs) are small non-coding molecules which silence gene expression of target gene (s) at posttranscriptional level. They are key regulators of cell cycle, apoptosis, anti-cancer drug responsiveness and metastasis.