Open AccessTumor suppressive effects of WEE1 gene silencing could not enhance immunopotentiation effects of CD80 and 4-1BBL co-stimulation in human T cells
Author(s) -
Naghmeh Ghiasi,
Mojtaba Habibagahi,
Rozita Rosli,
Abbas Ghaderi,
Khatijah Yusoff,
Ahmad Hosseini,
Saifollah Abdullah,
Mansooreh Jaberipour
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.147746
Subject(s) - gene silencing , cd80 , stimulation , gene , cancer research , chemistry , biology , cd40 , cytotoxic t cell , endocrinology , in vitro , biochemistry
Activation of T cells against tumors by recruiting co-stimulatory molecules has been an attractive approach for cancer immunotherapy. Reports suggested that targeting different genes in tumors might also boost T cell-mediated tumor destruction.