Open AccessCyclooxygenase-2 expression is associated with elevated aspartate aminotransferase level in hepatocellular carcinoma
Author(s) -
Eman A. Bayomi,
Ahmed B. Barakat,
Maha A. El-Bassuoni,
Randa M. Talaat,
Mervat M. El-Deftar,
Sabrin A Abdel Wahab,
Ayman M. Metwally
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.147692
Subject(s) - hepatocellular carcinoma , cyclooxygenase , medicine , gastroenterology , chemistry , enzyme , biochemistry
Cyclooxygenase-2 (COX-2), the inducible rate-limiting enzyme of prostaglandins biosynthesis, is involved in the pathogenesis of many chronic inflammation-related human malignancies including hepatocellular carcinoma (HCC). However, its clinical significance in HCC remains obscure. The aim of our study was to evaluate COX-2 expression in HCC and correlate its expression to both clinicopathological parameters and patients survival.