Open AccessLigustrazine induces apoptosis of breast cancer cells in vitro and in vivo
Author(s) -
Jun Pan,
Jin Shang,
Guoqin Jiang,
ZhiXue Yang
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.147378
Subject(s) - in vivo , apoptosis , in vitro , flow cytometry , pharmacology , cell growth , viability assay , mtt assay , cell culture , chemistry , cancer cell , cell cycle , cancer research , cancer , medicine , biology , immunology , biochemistry , genetics , microbiology and biotechnology
Ligustrazine, the active ingredient present in Umbelliferae plant roots used in Chinese medicine, plays a vital role in reversing multidrug resistance in tumors. This study aims to investigate its anticancer activity and underlying mechanisms in human breast cancer cells in vitro and in vivo.