Open AccessInvestigation of simvastatin-induced apoptosis and cell cycle arrest in cancer stem cells of MCF-7
Author(s) -
Mohammad H. Afzali,
Melody Vatankhah,
Seyed Nasser Ostad
Publication year - 2016
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.146127
Subject(s) - simvastatin , mcf 7 , cancer stem cell , cell cycle , apoptosis , cytotoxic t cell , stem cell , flow cytometry , cancer research , viability assay , statin , cancer , cell cycle checkpoint , cancer cell , pharmacology , chemistry , medicine , biology , immunology , in vitro , microbiology and biotechnology , biochemistry , human breast
Recent studies have shown the association between statins use and cancer risk reduction. Furthermore the importance of cancer stem cells (CSCs) in tumor initiation, progression and migration has been firmly established in a variety of solid tumors. Hence, the effective targeting of breast CSCs has a potential to improve cancer treatment outcome significantly.