Regulation of demethylation and re-expression of RASSF1A gene in hepatocellular carcinoma cell lines treated with NCTD in vitro | Zendy

Min Xu | Zendy; Yong Wang | Zendy; Zhen-Hai Di | Zendy; Jian Zhang | Zendy; Xue-Qun Mao | Zendy; Hai-Bo Sun | Zendy

Open Access

Regulation of demethylation and re-expression of RASSF1A gene in hepatocellular carcinoma cell lines treated with NCTD in vitro

Author(s) -

Min Xu,

Yong Wang,

Zhen-Hai Di,

Jian Zhang,

Xue-Qun Mao,

Hai-Bo Sun

Publication year - 2015

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.146126

Subject(s) - cantharidin , methylation , apoptosis , cell growth , hepatocellular carcinoma , cell culture , demethylation , microbiology and biotechnology , in vitro , cell , cancer research , chemistry , dna methylation , biology , gene expression , gene , biochemistry , genetics , organic chemistry

Hepatocellular carcinoma, a lethal malignant neoplasm with poor prognosis, has dismal results of surgical resection and chemoradiotherapy. Norcantharidin (NCTD), the demethylated analog of cantharidin derived from a traditional Chinese medicine, Mylabris, has been used in the treatment of cancer. However, the detailed mechanisms underlying this process are generally unclear.

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