Open AccessRegulation of demethylation and re-expression of RASSF1A gene in hepatocellular carcinoma cell lines treated with NCTD in vitro
Author(s) -
Yong Wang,
Min Xu,
Di Zhang,
Jian Zhang,
Xue-Qun Mao,
Hongwei Sun
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.146126
Subject(s) - cantharidin , methylation , apoptosis , cell growth , hepatocellular carcinoma , cell culture , demethylation , microbiology and biotechnology , in vitro , cell , cancer research , chemistry , dna methylation , biology , gene expression , gene , biochemistry , genetics , organic chemistry
Hepatocellular carcinoma, a lethal malignant neoplasm with poor prognosis, has dismal results of surgical resection and chemoradiotherapy. Norcantharidin (NCTD), the demethylated analog of cantharidin derived from a traditional Chinese medicine, Mylabris, has been used in the treatment of cancer. However, the detailed mechanisms underlying this process are generally unclear.