Aurora-A kinase: Potential tumor marker of osteosarcoma | Zendy

Xiaozhong Zhu | Zendy; Jiong Mei | Zendy; Zhiyuan Wang | Zendy

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Aurora-A kinase: Potential tumor marker of osteosarcoma

Author(s) -

Xiaozhong Zhu,

Jiong Mei,

Zhiyuan Wang

Publication year - 2014

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.145804

Subject(s) - osteosarcoma , cancer research , aurora a kinase , aurora kinase , mitosis , centrosome , aurora inhibitor , regulator , kinase , biology , oncogene , metastasis , aurora b kinase , cell cycle , microbiology and biotechnology , spindle apparatus , cell , cancer , genetics , gene , cell division

Aurora kinase family is a group of serine/threonine protein kinase. It is the main regulator in mitosis, including centrosome regulation, spindle formation, and chromosome separation. Aurora-A is an oncogene that is highly expressed in various human tumors, including osteosarcoma. Its high expression level and malignance and tumor metastasis are correlated. Aurora-A is a potential tumor marker. The progress of Aurora-A kinase in tumor research is summarized in this article.

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