Open AccessAurora-A kinase: Potential tumor marker of osteosarcoma
Author(s) -
Xiaoyan Zhu,
Jiong Mei,
Zhiyuan Wang
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.145804
Subject(s) - osteosarcoma , cancer research , aurora a kinase , aurora kinase , mitosis , centrosome , aurora inhibitor , regulator , kinase , biology , oncogene , metastasis , aurora b kinase , cell cycle , microbiology and biotechnology , spindle apparatus , cell , cancer , genetics , gene , cell division
Aurora kinase family is a group of serine/threonine protein kinase. It is the main regulator in mitosis, including centrosome regulation, spindle formation, and chromosome separation. Aurora-A is an oncogene that is highly expressed in various human tumors, including osteosarcoma. Its high expression level and malignance and tumor metastasis are correlated. Aurora-A is a potential tumor marker. The progress of Aurora-A kinase in tumor research is summarized in this article.