Open AccessProtective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction
Author(s) -
Erkan Cüre,
Aynur Kırbaş,
Levent Tümkaya,
Yıldıray Kalkan,
Arif Yılmaz,
Süleyman Yüce
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.140809
Subject(s) - methotrexate , medicine , pharmacology , tumor necrosis factor alpha , infliximab , intraperitoneal injection , nitric oxide , necrosis , drug
Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-α) has a protective effect against mtx-induced hepatotoxicity.