Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction | Zendy

Erkan Cüre | Zendy; Aynur Kırbaş | Zendy; Levent Tümkaya | Zendy; Medine Cumhur Cüre | Zendy; Yıldıray Kalkan | Zendy; Arif Yılmaz | Zendy; Süleyman Yüce | Zendy

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Protective effect of infliximab on methotrexate-induced liver injury in rats: Unexpected drug interaction

Author(s) -

Erkan Cüre,

Aynur Kırbaş,

Levent Tümkaya,

Medine Cumhur Cüre,

Yıldıray Kalkan,

Arif Yılmaz,

Süleyman Yüce

Publication year - 2015

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.140809

Subject(s) - methotrexate , medicine , pharmacology , tumor necrosis factor alpha , infliximab , intraperitoneal injection , nitric oxide , necrosis , drug

Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-α) has a protective effect against mtx-induced hepatotoxicity.

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