Open AccessBevacizumab alleviates radiation-induced brain necrosis: A report of four cases
Author(s) -
Xiangpan Li,
Yuxin Chu,
Xiaofei Wu,
Li Na,
Tong Xu,
Ximing Xu,
Changli Ruan,
Weiguo Hu,
Qing Song
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.140782
Subject(s) - bevacizumab , medicine , brain metastasis , necrosis , radiation therapy , brain edema , lung cancer , lesion , glioma , brainstem , cerebral edema , brain tumor , metastasis , cancer , surgery , pathology , chemotherapy , cancer research
To analyze the therapeutic effect of bevacizumab on radiation-induced brain necrosis. Four radiation-induced brain necrosis patients, administered with bevacizumab at a dose of 7.5 mg/kg every 3 weeks, 2 times. One case of brain metastasis of lung cancer and one case of nasopharyngeal carcinoma with brain necrosis after radiotherapy. However, their physical signs disappeared after the treatment with bevacizumab. One case of brainstem lesion and one case of brain glioma patient showed a transient improvement in signs and symptoms after treatment with bevacizumab. Bevacizumab can significantly alleviate the radiation-induced brain edema, and can improve the symptoms successively.