Bevacizumab alleviates radiation-induced brain necrosis: A report of four cases | Zendy

Weiguo Hu | Zendy; Song Qi-bin | Zendy; Xiangpan Li | Zendy; Yuxin Chu | Zendy; Xiaofei Wu | Zendy; Li Na | Zendy; Xu Tang-Peng | Zendy; Xiaotao Xu | Zendy; Changli Ruan | Zendy

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Bevacizumab alleviates radiation-induced brain necrosis: A report of four cases

Author(s) -

Weiguo Hu,

Song Qi-bin,

Xiangpan Li,

Yuxin Chu,

Xiaofei Wu,

Li Na,

Xu Tang-Peng,

Xiaotao Xu,

Changli Ruan

Publication year - 2015

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.140782

Subject(s) - bevacizumab , medicine , brain metastasis , necrosis , radiation therapy , brain edema , lung cancer , lesion , glioma , brainstem , cerebral edema , brain tumor , metastasis , cancer , surgery , pathology , chemotherapy , cancer research

To analyze the therapeutic effect of bevacizumab on radiation-induced brain necrosis. Four radiation-induced brain necrosis patients, administered with bevacizumab at a dose of 7.5 mg/kg every 3 weeks, 2 times. One case of brain metastasis of lung cancer and one case of nasopharyngeal carcinoma with brain necrosis after radiotherapy. However, their physical signs disappeared after the treatment with bevacizumab. One case of brainstem lesion and one case of brain glioma patient showed a transient improvement in signs and symptoms after treatment with bevacizumab. Bevacizumab can significantly alleviate the radiation-induced brain edema, and can improve the symptoms successively.

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