Open AccessAbsence of p53 gene mutations in mice colon pre-cancerous stage induced by o-nitrotoluene
Author(s) -
Nahed Ahmed Hussien
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.140773
Subject(s) - exon , single strand conformation polymorphism , point mutation , gene , biology , coding region , colorectal cancer , pathogenesis , microbiology and biotechnology , cancer research , mutation , genetics , cancer , immunology
p53 gene is one of the most frequently mutated genes found in the human colonic tumors. Mice have been used as an experimental model to study the pathogenesis of colon cancer in humans. The alterations in cancer genes and proteins found in the mouse large intestinal tumors included mutations which are hallmarks of human colon cancer, probably contributed to the pathogenesis of the large intestinal carcinomas in mice following o-nitrotoluene (o-nt) exposure.