Open AccessSignet ring cell neuroendocrine tumor liver with mesenteric metastasis
Author(s) -
Sheefa Haq,
Vineeta Vijay Batra,
Kaushik Majumdar,
Amit Javed,
Anil Agarwal,
Puja Sakhuja
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.139604
Subject(s) - signet ring cell , pathology , metastasis , cytokeratin , chromogranin a , neuroendocrine tumors , adenocarcinoma , glycocalyx , medicine , signet ring cell carcinoma , immunohistochemistry , cancer , immunology
Primary hepatic signet ring cell neuroendocrine tumor (NET) is extremely rare, and may show both neuroendocrine and glandular differentiation. Unlike the usual signet ring cells of adenocarcinoma, these cells are characterized by mucin negative, cytokeratin and chromogranin positive intracytoplasmic vacuoles resembling signet ring cells. These tumors are usually well demarcated surgically resectable lesions. To the best of our knowledge, we report the fifth case of primary hepatic signet ring cell NET, with the present case bearing multiple hepatic space occupying lesions and mesenteric metastasis. Due to very few isolated reports, prognosis of NET with signet ring cell morphology is largely unknown. Documentation of this case with review of related literature may enrich the existing knowledge regarding the outcome and management of this rare tumor