Open AccessNeuroendocrine carcinoma of the tongue
Author(s) -
Ebrahim Esmati,
Mohammad Babaei,
Amir Hassan Matini,
Monir Sadat Mirai Ashtiani,
Ehsan Akbari Hamed,
Nabil Hassan,
Farideh Razi,
Maryam Ganjalikhani
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.139395
Subject(s) - chromogranin a , synaptophysin , medicine , pathology , carcinoma , immunohistochemistry , tongue , neuroendocrine differentiation , cytokeratin , neuroendocrine tumors , biopsy , tongue neoplasm , squamous carcinoma , cancer , prostate cancer
Neuroendocrine carcinoma usually originates from lung. Few data exist in the literature regarding neuroendocrine carcinoma of the tongue. Patient data including history, surgical procedure, histology, and radiology investigations were collected and summarized. A 40-year-old woman was referred after partial glossectomy. Squamous mucosa with neoplasm and cells with round nuclei and light cytoplasm was reported in the tongue biopsy. Immunohistochemistry (IHC) staining was positive for cytokeratin, neuron specific enolase, synaptophysin and chromogranin and negative for leukocyte common antigen. This case showed a high proliferative activity (Ki-67 labeling index were 60%). These IHC findings were in favor of poorly differentiated neuroendocrine carcinoma. After surgery, she received chemotherapy and chemoradiation. The diagnosis of neuroendocrine tumors in the present case is based on immunohistochemical markers and cellular shapes. Postoperative chemoradiotherapy is a critical element of therapy for head and neck high-grade neuroendocrine carcinomas, our patient received this treatment after surgery