Open AccessDownregulation of β-catenin decreases the tumorigenicity, but promotes epithelial-mesenchymal transition in breast cancer cells
Author(s) -
Kai Chen,
Lijia Jiang,
Jing Wang,
Hongyi Zhang,
Xiaoying Wang,
Dengyu Cheng,
Jun Dou
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.139378
Subject(s) - small hairpin rna , vimentin , epithelial–mesenchymal transition , transfection , gene knockdown , cell growth , wnt signaling pathway , cancer research , catenin , cell , microbiology and biotechnology , downregulation and upregulation , cell culture , mesenchymal stem cell , chemistry , biology , signal transduction , immunology , gene , biochemistry , immunohistochemistry , genetics
Wnt/β-catenin signaling pathway plays a key role in human breast cancer progression. In this study, we down regulated β-catenin expression in human breast cancer MDA-MB-231 cells and investigated the effect of β-catenin knockdown on the cell biological characteristics.