Downregulation of β-catenin decreases the tumorigenicity, but promotes epithelial-mesenchymal transition in breast cancer cells | Zendy

Jun Dou | Zendy; Kai Cai | Zendy; Longwei Jiang | Zendy; Jing Wang | Zendy; Hongyi Zhang | Zendy; Xiaoying Wang | Zendy; Dengyu Cheng | Zendy

Open Access

Downregulation of β-catenin decreases the tumorigenicity, but promotes epithelial-mesenchymal transition in breast cancer cells

Author(s) -

Jun Dou,

Kai Cai,

Longwei Jiang,

Jing Wang,

Hongyi Zhang,

Xiaoying Wang,

Dengyu Cheng

Publication year - 2014

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.139378

Subject(s) - small hairpin rna , vimentin , epithelial–mesenchymal transition , transfection , gene knockdown , cell growth , wnt signaling pathway , cancer research , catenin , cell , microbiology and biotechnology , downregulation and upregulation , cell culture , mesenchymal stem cell , chemistry , biology , signal transduction , immunology , gene , biochemistry , immunohistochemistry , genetics

Wnt/β-catenin signaling pathway plays a key role in human breast cancer progression. In this study, we down regulated β-catenin expression in human breast cancer MDA-MB-231 cells and investigated the effect of β-catenin knockdown on the cell biological characteristics.

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