Open AccessA rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult
Author(s) -
H B Sridevi,
P R Shanthala,
C. V. Raghuveer,
Ananth K Prabhu,
Jallaluddin K C Akbar,
G S Shivaprasad,
Pooja K Suresh,
Sanjay Navani
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.139338
Subject(s) - anaplastic large cell lymphoma , cd30 , medicine , chop , lymphoma , biopsy , pathology , large cell , anaplastic lymphoma kinase , lesion , cancer , adenocarcinoma , malignant pleural effusion , lung cancer
Cutaneous anaplastic large cell lymphoma can present either as a primary disease or as secondary to a pre-existing systemic anaplastic lymphoma. Distinguishing primary cutaneous anaplastic lymphoma (PC-ALCL) from its systemic counterpart requires a complete clinical and laboratory workup. We hereby report a case of PC-ALCL in a young adult, who presented with unusual rapidly progressive ulcerated mass in the neck. Biopsy showed anaplastic large cells, which were strongly positive for CD30 and CD25 but ALK1 gene product was negative. Clinical examination and computed tomography (CT) scan ruled out extracutaneous involvement. Chemotherapy with 6 cycles of CHOP regimen was planned and on follow-up, a complete remission of the lesion was attained