Cyclo-oxygenase-2 expression in oral squamous cell carcinoma | Zendy

Maryam Seyedmajidi | Zendy; Shahryar Shafaee | Zendy; Sepideh Siadati | Zendy; Monireh Khorasani | Zendy; Ali Bijani | Zendy; Nafiseh Ghasemi | Zendy

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Cyclo-oxygenase-2 expression in oral squamous cell carcinoma

Author(s) -

Maryam Seyedmajidi,

Shahryar Shafaee,

Sepideh Siadati,

Monireh Khorasani,

Ali Bijani,

Nafiseh Ghasemi

Publication year - 2014

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.138205

Subject(s) - immunohistochemistry , dysplasia , carcinogenesis , medicine , malignancy , pathology , tongue , carcinoma , oral mucosa , staining , cancer

Many evidences showed that cyclooxygenase-2 (COX-2), an enzyme that catalyzes the synthesis of prostaglandins, has an important role in carcinogenesis. It has been observed in experimental models that selective COX-2 inhibitors suppress the formation of tumors including tongue carcinoma. The aim of this study was to investigate the immunohistochemical expression of COX-2 in oral squamous cell carcinoma (OSCC) compared to normal oral mucosa and oral dysplasia.

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