Open AccessCyclo-oxygenase-2 expression in oral squamous cell carcinoma
Author(s) -
Maryam Seyedmajidi,
Shahryar Shafaee,
Sepideh Siadati,
Monireh Khorasani,
Ali Bijani,
Nasrin Ghasemi
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.138205
Subject(s) - immunohistochemistry , dysplasia , carcinogenesis , medicine , malignancy , pathology , tongue , carcinoma , oral mucosa , staining , cancer
Many evidences showed that cyclooxygenase-2 (COX-2), an enzyme that catalyzes the synthesis of prostaglandins, has an important role in carcinogenesis. It has been observed in experimental models that selective COX-2 inhibitors suppress the formation of tumors including tongue carcinoma. The aim of this study was to investigate the immunohistochemical expression of COX-2 in oral squamous cell carcinoma (OSCC) compared to normal oral mucosa and oral dysplasia.