Open AccessChanges in lymphocytes′ telomerase activity by 4-1BB costimulation
Author(s) -
Hosseini Ahmad,
Mansooreh Jaberipour,
Masoodi Fereshteh,
Mojtaba Habibagahi
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.137906
Subject(s) - cd80 , telomerase , cd28 , cd86 , biology , telomerase reverse transcriptase , microbiology and biotechnology , cytotoxic t cell , cytokine , cd40 , cancer research , t cell , immunology , immune system , biochemistry , in vitro , gene
Lymphocytes are exceptional among somatic cells as these cells can induce telomerase enzyme after antigen stimulation to compensate chromosomal loss during rapid cell division. Activation of telomerase in lymphocytes needs CD28 signal, which simultaneously costimulates T cells during activation. 4-1BB of tumor necrosis factor superfamily also has been shown to costimulate T cells. Herein, we investigated changes in telomerase activity of lymphocytes during longitudinal cultures when T cells costimulated by CD80 or 4-1BB ligand or both molecules in conjunction with anti-CD3 stimulation.