Changes in lymphocytes′ telomerase activity by 4-1BB costimulation | Zendy

Habibagahi Mojtaba | Zendy; HosseiniTashnizi Ahmad | Zendy; Mansooreh Jaberipour | Zendy; Masoodi Fereshteh | Zendy

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Changes in lymphocytes′ telomerase activity by 4-1BB costimulation

Author(s) -

Habibagahi Mojtaba,

HosseiniTashnizi Ahmad,

Mansooreh Jaberipour,

Masoodi Fereshteh

Publication year - 2014

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.137906

Subject(s) - cd80 , telomerase , cd28 , cd86 , biology , telomerase reverse transcriptase , microbiology and biotechnology , cytotoxic t cell , cytokine , cd40 , cancer research , t cell , immunology , immune system , biochemistry , in vitro , gene

Lymphocytes are exceptional among somatic cells as these cells can induce telomerase enzyme after antigen stimulation to compensate chromosomal loss during rapid cell division. Activation of telomerase in lymphocytes needs CD28 signal, which simultaneously costimulates T cells during activation. 4-1BB of tumor necrosis factor superfamily also has been shown to costimulate T cells. Herein, we investigated changes in telomerase activity of lymphocytes during longitudinal cultures when T cells costimulated by CD80 or 4-1BB ligand or both molecules in conjunction with anti-CD3 stimulation.

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