Open AccessCarvedilol suppresses migration and invasion of malignant breast cells by inactivating Src involving cAMP/PKA and PKCδ signaling pathway
Author(s) -
Dezong Gao,
Zhigui Ma,
Qinye Fu,
Zhengping Yu
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.137664
Subject(s) - proto oncogene tyrosine protein kinase src , cell migration , signal transduction , cancer research , protein kinase c , cancer cell , protein kinase a , transfection , apoptosis , small interfering rna , kinase , breast cancer , biology , microbiology and biotechnology , chemistry , cancer , medicine , endocrinology , cell culture , cell , biochemistry , genetics
Carvedilol (CAR) can inhibit cell growth and induce cell apoptosis in breast cancer in vitro. But it is still not known whether CAR affects the migration and invasion of breast cancer cells.