Open AccessClear cell hepatocellular carcinoma
Author(s) -
Puja Sakhuja,
Pramod Kumar Mishra,
Rajendiran Rajesh,
Ashok Sharma,
Ranjana Gondal,
Meeta Singh
Publication year - 2015
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.136041
Subject(s) - hepatocellular carcinoma , carcinoembryonic antigen , pathology , immunohistochemistry , eosinophilic , clear cell , histology , medicine , glypican 3 , liver cancer , polyclonal antibodies , carcinoma , clear cell carcinoma , cancer , antigen , cancer research , immunology
Hepatocellular carcinoma (HCC) is a common cancer world-wide with a higher incidence in Asia. Clear cell variant of HCC (CCHCC) has a frequency ranging from 0.4% to 37%. The presence of 90-100% clear cells is rare. In the present case, a 35-year-old female patient presented with fever and a large abdominal mass in the right hypochondrium. Histology of the tumor revealed >95% clear cells and after taking multiple sections from different areas of tumor only few scattered cells with eosinophilic cytoplasm were found. Immunohistochemistry with Hep Par 1, Glypican 3 and polyclonal carcinoembryonic antigen were negative as were all other markers for metastatic clear cell tumors. Histological diagnosis was based on routine H and E sections showing a histological pattern of architecture with thickened trabeculae. We describe a rare case of CCHCC with >95% clear cells and no immunoreactivity in tumor cells in a non-cirrhotic liver