Open AccessAbsence of correlation between serum CRP levels and mitochondrial D-loop DNA mutations in gastro-oesophageal adenocarcinoma
Author(s) -
Benjamin Tan,
Richard J E Skipworth,
Nick Wheelhouse,
Kenneth C.H. Fearon,
James A. Ross
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.131458
Subject(s) - mitochondrial dna , adenocarcinoma , carcinogenesis , mutation , biology , cancer , d loop , gastro , mutation frequency , microbiology and biotechnology , cancer research , gastroenterology , pathology , genetics , medicine , gene , disease , reflux
Both inflammation and mitochondrial DNA (mtDNA) mutation are thought to play a role in the many human cancers. The aim of this study was to evaluate the relationship between inflammation and accumulation of mitochondrial DNA (mtDNA) mutations in the D-loop region in carcinogenesis of gastro-oesophageal adenocarcinomas.