Open AccessLambda light chain myeloma presenting as nodular hepatic lesion: A clinical rarity
Author(s) -
Santanu Kumar Pal,
Bitoti Chattopadhyay,
Argha Chatterjee,
Biswamit Bhattacharya
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.131409
Subject(s) - medicine , multiple myeloma , plasmacytoma , serum protein electrophoresis , immunoglobulin light chain , dexamethasone , lesion , jaundice , thalidomide , bone marrow , abdominal pain , pathology , gastroenterology , radiology , antibody , monoclonal , immunology , monoclonal antibody
We report a case of a 63-year-old lady presenting with pain in the right hypochondrium, jaundice, anorexia, and firm tender hepatomegaly with remarkably high serum alkaline phosphatase. Abdominal ultrasonography revealed a hypoechoic solid space-occupying lesion in right lobe of liver which was cytologically diagnosed as hepatic plasmacytoma. Serum and urine immunofixation electrophoresis, serum free light chain ratio, and bone marrow examination further confirmed the presence of lambda light chain multiple myeloma in the background. The patient achieved complete remission after four cycles of induction therapy with thalidomide and dexamethasone protocol and consolidated with further four cycles of the same regimen.