Open AccessImmunohistochemical expression of syndecan-1 in oral dysplastic epithelium
Author(s) -
B Lakkam,
B Majage,
Madhusudan Astekar,
R S Gugwad,
G.V. Giri,
Sindhura Ramasahayam
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.131407
Subject(s) - syndecan 1 , pathology , immunohistochemistry , epithelial dysplasia , dysplasia , h&e stain , cancer , epithelium , antibody , basal cell , medicine , biology , cell , immunology , genetics
In stratified squamous epithelia, syndecan-1 is proposed to function as a cellto cell adhesion molecule, and plays an important role in regulation of cell growth and differentiation during the developmental process. Oral cancer is a disease with complex etiology, so biological behavior in carcinomas preceded by dysplastic states is difficult to assess and predict its prognosis. Hence, syndecan-1, a recently recognized tumor marker has been proved to be an eminent diagnostic and prognostic tool in assessing biological behavior of various potentially premalignant andmalignant lesions.