Anti-cancer Effects of CME-1, a Novel Polysaccharide, Purified from the Mycelia of Cordyceps sinensis against B16-F10 Melanoma Cells | Zendy

YungKai Huang | Zendy; JoenRong Sheu | Zendy; Thanasekaran Jayakumar | Zendy; ChongChi Chiu | Zendy; Shwu-Huey Wang | Zendy; DuenSuey Chou | Zendy

Open Access

Anti-cancer Effects of CME-1, a Novel Polysaccharide, Purified from the Mycelia of Cordyceps sinensis against B16-F10 Melanoma Cells

Author(s) -

YungKai Huang,

JoenRong Sheu,

Thanasekaran Jayakumar,

ChongChi Chiu,

Shwu-Huey Wang,

DuenSuey Chou

Publication year - 2014

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.131365

Subject(s) - cordyceps , mapk/erk pathway , p38 mitogen activated protein kinases , kinase , signal transduction , protein kinase a , melanoma , cancer cell , western blot , microbiology and biotechnology , biology , cancer research , chemistry , cancer , biochemistry , botany , gene , genetics

Matrix metalloproteinases (MMPs) play important roles in the invasion and migration of cancer cells. In melanoma, several signaling pathways are constitutively activated. Among these, the mitogen-activated protein kinase (MAPKs) signaling pathways are activated through multiple signal transduction molecules and appear to play major roles in melanoma progression. Therefore, the inhibition of MAPK signaling might be a crucial role for the treatment of melanoma cancer.

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