Open AccessAnti-cancer Effects of CME-1, a Novel Polysaccharide, Purified from the Mycelia of Cordyceps sinensis against B16-F10 Melanoma Cells
Author(s) -
Thanasekaran Jayakumar,
Chih-Yi Chiu,
Shwu Huey Wang,
Duen Suey Chou,
Yung Kai Huang,
Joen Rong Sheu
Publication year - 2014
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.131365
Subject(s) - cordyceps , mapk/erk pathway , p38 mitogen activated protein kinases , kinase , signal transduction , protein kinase a , melanoma , cancer cell , western blot , microbiology and biotechnology , biology , cancer research , chemistry , cancer , biochemistry , botany , gene , genetics
Matrix metalloproteinases (MMPs) play important roles in the invasion and migration of cancer cells. In melanoma, several signaling pathways are constitutively activated. Among these, the mitogen-activated protein kinase (MAPKs) signaling pathways are activated through multiple signal transduction molecules and appear to play major roles in melanoma progression. Therefore, the inhibition of MAPK signaling might be a crucial role for the treatment of melanoma cancer.