Open AccessHSP70 induces TLR4 signaling in oral squamous cell carcinoma: An immunohistochemical study
Author(s) -
Sindhu Nair,
Vijayalakshmi S Kotrashetti,
Raghavendra Nayak,
Kishore Bhat,
Pradeep Somannavar,
Jagadish Hosmani
Publication year - 2013
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.126460
Subject(s) - carcinogenesis , tlr4 , proinflammatory cytokine , cancer research , biology , chemokine , cytokine , cancer , hsp70 , immunology , immune system , heat shock protein , inflammation , biochemistry , genetics , gene
Toll like receptors play an important role in innate and adaptive immune responses. Heat shock proteins play a significant role in cell proliferation, differentiation and oncogenesis. HSP70 acts as one of the ligands of TLR4 and binds to it in a CD14 dependent fashion to bring about proinflammatory cytokine production leading to an anti-tumor response. On the contrary, TLR4 has been implicated in carcinogenesis by secretion of anti-apoptotic proteins. Thus the aim of this study was to compare and correlate the association of HSP70 and TLR4 in various grades of oral squamous cell carcinoma.