HSP70 induces TLR4 signaling in oral squamous cell carcinoma: An immunohistochemical study | Zendy

Sindhu Nair | Zendy; Vijayalakshmi Kotrashetti | Zendy; Ramakant Nayak | Zendy; Kishore Bhat | Zendy; Pradeep Somannavar | Zendy; Jagadish Hosmani | Zendy

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HSP70 induces TLR4 signaling in oral squamous cell carcinoma: An immunohistochemical study

Author(s) -

Sindhu Nair,

Vijayalakshmi Kotrashetti,

Ramakant Nayak,

Kishore Bhat,

Pradeep Somannavar,

Jagadish Hosmani

Publication year - 2013

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.126460

Subject(s) - carcinogenesis , tlr4 , proinflammatory cytokine , cancer research , biology , chemokine , cytokine , cancer , hsp70 , immunology , immune system , heat shock protein , inflammation , biochemistry , genetics , gene

Toll like receptors play an important role in innate and adaptive immune responses. Heat shock proteins play a significant role in cell proliferation, differentiation and oncogenesis. HSP70 acts as one of the ligands of TLR4 and binds to it in a CD14 dependent fashion to bring about proinflammatory cytokine production leading to an anti-tumor response. On the contrary, TLR4 has been implicated in carcinogenesis by secretion of anti-apoptotic proteins. Thus the aim of this study was to compare and correlate the association of HSP70 and TLR4 in various grades of oral squamous cell carcinoma.

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