Open AccessSignal transducers and activators of transcription 3 function in lung cancer
Author(s) -
Chunjie Li,
Yue-Chuan Li,
Dongrui Zhang,
Jianhui Pan
Publication year - 2013
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.119100
Subject(s) - stat3 , stat , signal transduction , stat protein , janus kinase , cancer research , carcinogenesis , lung cancer , transcription factor , biology , context (archaeology) , jak stat signaling pathway , microbiology and biotechnology , transcription (linguistics) , cancer , medicine , oncology , tyrosine kinase , genetics , gene , paleontology , linguistics , philosophy
Constitutively activation of signal transducers and activators of transcription 3 (STAT3) proteins are involved in multiple aberrant signaling pathway-oncogenic pathways, including pathways regulating tumor cell survival. STAT3 is one of the second messengers in the Janus activated family kinases/STAT signaling pathway and is regulated by many different factors involving tumorigenesis. Given that the activation of STAT3 is observed in nearly 50% of Lung cancers and more and more researches regarding STAT3 in tumors, here in, we reviewed the contribution of STAT3 to lung cancer growth and progression and then the context in which positive and negative regulation of STAT activation leading to cell competition provides a mechanism for therapeutic intervention for specific cancers is discussed.