Open AccessLow-grade myofibroblastic sarcoma of the larynx: A rare entity with review of literature
Author(s) -
Divya Khosla,
Budhi Singh Yadav,
Ritesh Kumar,
Sushmita Ghoshal,
Kim Vaiphei,
Roshan Verma,
Suresh C. Sharma
Publication year - 2013
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.113387
Subject(s) - larynx , anaplasia , laryngectomy , rare disease , medicine , radiation therapy , sarcoma , lesion , pathology , radiology , disease , surgery
Mesenchymal neoplasms of the larynx are rare and make up approximately 0.3% to 1.0% of all malignancies at this location. Low grade myofibroblastic sarcoma (LGMS) of larynx is a rare entity. We describe a rare case of LGMS of larynx who presented with complaint of hoarseness of voice. The patient was treated with total laryngectomy plus partial pharyngectomy followed by post-operative radiotherapy. Histopathologically, the lesion was composed of spindle cells that manifested variable cellular anaplasia and expressed smooth muscle actin (SMA) and focally S-100.One of the resection limits was involved so patient was given post-operative radiotherapy. The patient is alive and disease free 14 months after surgery. The characteristic clinical, histopathological features and treatment of this case are described with a literature review.