The significance of mismatch repair genes in gastric cancer | Zendy

You Jin Jang | Zendy; HyeJeong Lee | Zendy; Eunjung Lee | Zendy; Jong-Han Kim | Zendy; SungSoo Park | Zendy; Seong-Heum Park | Zendy; Chong-Suk Kim | Zendy; YoungJae Mok | Zendy

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The significance of mismatch repair genes in gastric cancer

Author(s) -

You Jin Jang,

HyeJeong Lee,

Eunjung Lee,

Jong-Han Kim,

SungSoo Park,

Seong-Heum Park,

Chong-Suk Kim,

YoungJae Mok

Publication year - 2013

Publication title -

journal of cancer research and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 39

eISSN - 0973-1482

pISSN - 1998-4138

DOI - 10.4103/0973-1482.110382

Subject(s) - dna mismatch repair , microsatellite instability , cancer , carcinogenesis , dna repair , biology , gene , clinical significance , phenotype , cancer research , allele , genetics , oncology , medicine , microsatellite

Microsatellite instability (MSI) is a form of genetic instability characterized by new alleles not present in the normal genotype. This mutation occurs by altered DNA mismatch repair (MMR) genes. Studies of limited numbers of patients have reported conflicting results regarding the association of the MSI phenotype with gastric cancer. This study aims to evaluate the clinical significance of mismatch repair genes in gastric cancer.

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