Open AccessThe significance of mismatch repair genes in gastric cancer
Author(s) -
Hye Jeong Lee,
Young-Joo Jang,
Eun Jung Lee,
Jong Han Kim,
Sung Soo Park,
Seong Heum Park,
Chong Suk Kim,
Young Jae Mok
Publication year - 2013
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.110382
Subject(s) - dna mismatch repair , microsatellite instability , cancer , carcinogenesis , dna repair , biology , gene , clinical significance , phenotype , cancer research , allele , genetics , oncology , medicine , microsatellite
Microsatellite instability (MSI) is a form of genetic instability characterized by new alleles not present in the normal genotype. This mutation occurs by altered DNA mismatch repair (MMR) genes. Studies of limited numbers of patients have reported conflicting results regarding the association of the MSI phenotype with gastric cancer. This study aims to evaluate the clinical significance of mismatch repair genes in gastric cancer.