Open AccessA preliminary study on the radiation-resistance mechanism in ovarian cancer
Author(s) -
Ling Qi,
Hongmei Zhang,
LI Hai-hua,
Zhimin Ren,
Huiling Mao,
Yubing Chen,
Manhua Cui
Publication year - 2013
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.110346
Subject(s) - small hairpin rna , hela , transfection , apoptosis , microbiology and biotechnology , annexin , radiosensitivity , cancer cell , biology , chemistry , cell culture , cancer research , medicine , cancer , radiation therapy , biochemistry , genetics , gene knockdown
The present study was designed to explore the radiation-resistance mechanism by interfering in checkpoints kinase 1 (CHK1) and DNA-activated protein kinase (DNA-PK) genes with short hairpin RNA (shRNA) transfection into Skov3 cells derived from ovarian cancer and HeLa cells derived from cervical cancer.