Open AccessSkull-base Ewing sarcoma with multifocal extracranial metastases
Author(s) -
Sumit Thakar,
Sunil V. Furtado,
Nandita Ghosal,
Dilip Jethwani,
Anita Mahadevan,
Alangar S. Hegde
Publication year - 2012
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.106584
Subject(s) - clivus , medicine , skull , sarcoma , lesion , sinus (botany) , sphenoidal sinus , radiology , anatomy , pathology , paranasal sinuses , botany , biology , genus
Intracranial occurrence of Ewing sarcoma (ES) is unusual, with a skull-base location being anecdotal. We report a 29-year-old man who presented with rapidly progressive ophthalmoplegia, and was found to be harboring an infiltrative lesion involving the sphenoid sinus, sella, and clivus. He underwent trans-sphenoidal decompression of the lesion which was histologically suggestive of ES. He developed paraparesis 2 weeks after commencing adjuvant therapy. Imaging revealed two thoracic extradural lesions and florid vertebral and pulmonary metastases. This is the first report in indexed literature of a primary intracranial ES on the skull-base with disseminated extracranial disease.