Open AccessImmunohistochemical expression of IDH1 in gliomas: A tissue microarray-based approach
Author(s) -
Varuna Sipayya,
Ira Sharma,
Karam Chand Sharma,
Avninder Singh
Publication year - 2012
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.106567
Subject(s) - idh1 , immunohistochemistry , isocitrate dehydrogenase , glioma , pathology , astrocytoma , tissue microarray , oligodendroglioma , monoclonal antibody , ependymoma , biology , cancer research , medicine , antibody , immunology , mutant , gene , enzyme , biochemistry
Mutations in the gene encoding isocitrate dehydrogenase (IDH1) have been reported in gliomas. This study analyses a series of 184 glioma cases in a tissue microarray (TMA)-based approach to assess the frequency of R132H point mutations in formalin-fixed, paraffin-embedded tissue samples.