Open AccessPre-cancerous (DNA and chromosomal) lesions in professional sports
Author(s) -
Radhika Sharma,
Shailey,
Gursatej Gandhi
Publication year - 2012
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.106544
Subject(s) - dna damage , context (archaeology) , buccal swab , genome instability , analysis of variance , micronucleus test , comet assay , genetics , biology , medicine , physiology , dna , paleontology , toxicity
Exhaustive exercises may become detrimental, causing disturbance of intracellular oxidant-antioxidant balance and damage to macromolecules, leading to genomic instability when DNA/chromosomes get damaged. As these are precancerous lesions, cancer occurrence is probable. Because professional sports requires high-intensity training and increasing physical demand, there may occur cellular genomic instability.