Open AccessCorrelation of expression pattern of aquaporin-1 in primary central nervous system tumors with tumor type, grade, proliferation, microvessel density, contrast-enhancement and perilesional edema
Author(s) -
Prabal Deb,
Seerat Pal,
Vibha Dutta,
Dibyajyoti Boruah,
Vijai Chandran,
Harjinder Singh Bhatoe
Publication year - 2012
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.106542
Subject(s) - pathology , aquaporin 1 , medicine , edema , immunohistochemistry , microvessel , downregulation and upregulation , aquaporin 4 , biopsy , glial tumor , vascular endothelial growth factor , glioma , biology , cancer research , water channel , mechanical engineering , biochemistry , engineering , inlet , gene , vegf receptors
Brain edema, a hallmark of malignant brain tumors, continues to be a major cause of mortality. The underlying molecular mechanisms are poorly understood and thought to be mediated through membrane water-channels: aquaporins (AQP1,4,9). The abnormal upregulation of AQP1 in certain glial neoplasms has suggested a potential role in tumor pathogenesis, apart from being a novel target for newer therapeutic regimen. This study was undertaken to evaluate the expression of AQP1 in primary CNS tumors of various histologic types and grades, and its correlation with contrast-enhancement, perilesional edema, histomorphology, proliferation index and microvessel density.