Open AccessAcute non-ST elevation myocardial infarction following paclitaxel administration for ovarian carcinoma: A case report and review of literature
Author(s) -
Kalpesh Shah,
Sudeep Gupta,
Jaya Ghosh,
Jyoti Bajpai,
Amita Maheshwari
Publication year - 2012
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.103530
Subject(s) - medicine , myocardial infarction , paclitaxel , cardiology , chest pain , chemotherapy , ovarian cancer , regimen , coronary vasospasm , infarction , cancer , angina
We report a case of an acute non-ST elevation myocardial infarction (AMI) induced by paclitaxel in a patient with ovarian cancer. A 45-year-old premenopausal lady without any co-morbidity was started on the first cycle of neoadjuvant chemotherapy with paclitaxel-based regimen for advanced stage ovarian cancer. The patient developed chest pain 3 h after paclitaxel infusion with characteristic electrocardiographic changes of antero-apical myocardial infarction. The patient recovered on conservative medical management with reversion of electrocardiogram (ECG) changes. Cardiac ischemia and myocardial infarction, possibly due to coronary vasospasm, are rare adverse effects of paclitaxel with reported incidence of 0.26%. We have reported a case of paclitaxel-induced myocardial infarction with reversible cardiac dysfunction. The possibility of myocardial infarction should be considered in patients who develop chest pain or other symptoms after paclitaxel infusion.