Open AccessProtective effects of bioactive phytochemicals from Mentha piperita with multiple health potentials
Author(s) -
Seyedeh Maryam Sharafi,
Iraj Rasooli,
Parviz Owlia,
Masoud Taghizadeh,
Shakiba Darvish Alipoor Astaneh
Publication year - 2010
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.66926
Subject(s) - chemistry , antioxidant , antimicrobial , dpph , klebsiella pneumoniae , ferric reducing ability of plasma , lipid peroxidation , food science , uric acid , essential oil , traditional medicine , pharmacology , biochemistry , escherichia coli , biology , antioxidant capacity , medicine , organic chemistry , gene
Mentha piperita essential oil was bactericidal in order of E. coli> S. aureus > Pseudomonas aeruginosa > S. faecalis > Klebsiella pneumoniae. The oil with total phenolics of 89.43 ± 0.58 µg GAE/mg had 63.82 ± 0.05% DPPH inhibition activity with an IC (50) = 3.9 µg/ml. Lipid peroxidation inhibition was comparable to BHT and BHA. A 127% hike was noted in serum ferric-reducing antioxidant power. There was 38.3% decrease in WBCs count, while platelet count showed increased levels of 214.12%. Significant decrease in uric acid level and cholesterol/HDL and LDL/HDL ratios were recorded. The volatile oil displayed high cytotoxic action toward the human tumor cell line. The results of this study deserve attention with regard to antioxidative and possible anti-neoplastic chemotherapy that form a basis for future research. The essential oil of mint may be exploited as a natural source of bioactive phytopchemicals bearing antimicrobial and antioxidant potentials that could be supplemented for both nutritional purposes and preservation of foods.