Open AccessWithaferin-A induces apoptosis in osteosarcoma U2OS cell line via generation of ROS and disruption of mitochondrial membrane potential
Author(s) -
Huiliang Zhang,
Hong Zhang
Publication year - 2017
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.211042
Subject(s) - apoptosis , osteosarcoma , dapi , cell culture , withaferin a , chemistry , reactive oxygen species , microbiology and biotechnology , medicine , cancer research , biology , biochemistry , pathology , genetics , alternative medicine , withania somnifera
Withaferin-A (WF-A) is a well-known dietary compound isolated from Withania sominifera . It has tremendous pharmacological potential and has been shown to exhibit antiproliferative activity against several types of cancerous cells. Currently, the main focus of anti-cancer therapeutic development is to identify apoptosis inducing drug-like molecules. Osteosarcoma is a rare type of osteocancer, affecting human. The present study therefore focused on the evaluation of antitumor potential of WF-A against several osteosarcoma cell lines.