Open AccessCaffeic acid phenethyl ester (CAPE) prevents development of STZ-ICV induced dementia in rats
Author(s) -
Manish Kumar,
Chanchal Deep Kaur,
Nitin Bansal
Publication year - 2017
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.203974
Subject(s) - morris water navigation task , caffeic acid phenethyl ester , oxidative stress , neuroprotection , pharmacology , medicine , streptozotocin , antioxidant , elevated plus maze , dementia , endocrinology , caffeic acid , chemistry , hippocampus , biochemistry , diabetes mellitus , disease , anxiety , psychiatry
Chronic oxidative stress and inflammation severely affect the normal physiology of neurons and lead to neurodegenerative disorders such as Alzheimer's disease (AD). Polyphenols proved a boon in the prevention of dementia due to their antioxidant and neuroprotective potential. Caffeic acid phenethyl ester (CAPE) is a natural polyphenolic compound attributed with antioxidant, immunomodulatory, and neuroprotective properties.