Open AccessIn-vitro wound healing effect of 15-hydroxyprostaglandin dehydrogenase inhibitor from plant
Author(s) -
Sandeep Karna
Publication year - 2017
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.203971
Subject(s) - hacat , viability assay , pharmacology , ic50 , cell culture , in vivo , prostaglandin e , ec50 , wound healing , chemistry , in vitro , biology , biochemistry , immunology , genetics , microbiology and biotechnology
Prostaglandins (PGs) have short existence in vivo because they are rapidly metabolized by NAD + -dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) to 15-ketoprostaglandins. Inhibition of 15-PGDH causes elevated level of PGE 2 in cellular system. It will be valuable for the therapeutic management of diseases requiring elevated PGE 2 levels, like wound healing.