Open AccessCatha edulis extract induces H9c2 cell apoptosis by increasing reactive oxygen species generation and activation of mitochondrial proteins
Author(s) -
Syam Mohan,
Siddig Ibrahim Abdelwahab,
Yahya Hasan Hobani,
Suvitha Syam,
Adel Sharaf Al-Zubairi,
Rashad Al-sanousi,
Magbool E. Oraiby
Publication year - 2016
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.185732
Subject(s) - khat , acridine orange , cathinone , apoptosis , reactive oxygen species , propidium iodide , chemistry , pharmacology , traditional medicine , programmed cell death , biochemistry , medicine , dopamine , amphetamine
Catha edulis (Khat) is an evergreen shrub or small tree, traditionally used by various peoples of the Arabian Peninsula and Africa as an integral component of the socioeconomic traditions. It is believed that the psychostimulant nature and toxic nature of khat is primarily due to the presence of cathinone and cathine respectively. Studies have shown that khat chewing is closely associated with cardiac complications, especially myocardial infarction. Hence in this study, we exposed cathine-rich khat extract in a cardiomyoblast H9c2 (2-1) cell line to check the cell death mechanism.