Open AccessThe anticholinesterase properties of plants from the northeast of brazil selected by an ethnopharmacological study for disorders relating to the nervous system
Author(s) -
Valérium Thijan Nobre de Almeida e Castro,
Tadeu José da Silva Peixoto Sobrinho,
Allan Jonathan Chernichiarro Corrêa,
Thiago Antônio de Sousa Araújo,
Terezinha Gonçalves Da Silva,
Elba Lúcia Cavalcanti de Amorim
Publication year - 2016
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.182166
Subject(s) - acetylcholinesterase , aché , cholinesterase , acetylcholine , choline acetyltransferase , traditional medicine , medicinal plants , ricinus , biology , cholinergic , pharmacology , toxicology , enzyme , biochemistry , medicine , neuroscience
Various factors may trigger Alzheimer's disease and the cholinergic hypothesis, which is one of the most widely accepted, argues damage to the brain nuclei, may reduce the production of the choline acetyltransferase enzyme, and cause a decline in the synthesis of acetylcholine (ACh). Studies have thus focused on discovering molecules that are capable of inhibiting the action of cholinesterase enzymes that degrade ACh, thereby preventing the evolution of the disease.